The Brauer Museum boasts a collection of more than 3,000 American works of art from the mid-19th century to the present. Included are landscapes by Frederic E. Church, Asher B. Durand, and John F. Kensett; large late-19th century paintings by T. Alexander Harrison and Elizabeth Nourse; Impressionist paintings by Karl Anderson, Childe Hassam and Robert Reid; and urban realist paintings by William Glackens and John Sloan.

The museum also holds early modernist paintings by John Marin, Walt Kuhn and Georgia O’Keeffe. Other contemporary works include artists such as Elaine de Kooning, Ed Paschke, Andy Warhol, Chuck Close and Ansel Adams.