Leslie Paul earned her B.S. in Nursing from Valparaiso University in 1977, where she was a member of the Kappa Psi Omega sorority. She was a staff nurse at Green Hospital Scripps Clinic for 13 years, serving in various positions including clinical nurse instructor. Paul was instrumental in partnering with the dean to create the Virtual Nursing Learning Center. She is active in church and community and represented the San Diego chapter of the VU Guild at the 2003 Guild Convention.