Laura Rowe

Assistant Professor of Chemistry

Center for the Sciences 112
219.464.6255
laura.rowe@valpo.edu

Specialty

Bioanalytical chemistry

Education

Post-Doc – Cambridge University, U.K. (2009–2011)
Ph.D. in Bio-Analytical Chemistry – University of Kentucky (2008)
B.S. – University of Kentucky (2002)

Research Interests

Creating new fluorescent unnatural amino acids and evolving the translational machinery in E. coli to incorporate these unnatural amino acids into proteins, using various unnatural amino acids to make sensors and detection systems for important physiological analytes

Contributions

Patents:
  • Daunert, Sylvia; Deo, Sapna, Dikici, Emre; Rowe, Laura. Aequorin and obelin mutants with different wavelengths and bioluminescence and their uses in screening inhibitors of HIV-1 protease, U.S. Pat. Appl. Publ., 2008, Patent No. US20050214776.
  • Daunert, Sylvia; Joel, Smita; Turner, Kendrick; Rowe, Laura. Polypeptides, Systems, and Methods Useful for Detecting Glucose, 2011, Patent No. US20110117661.
  • Daunert, Sylvia; Bachas, Leonidas; Haley, Boyd; Joel, Smita; Moschou, Elizabeth; Turner, Kendrick; Rowe, Laura; Wang, Ping; Siegrist, Jonathan; Madou, Marc. Device for Detection of Molecules of Interest, U.S. Provisional Patent Application Serial Nos 60/954,269 and 60/954,348, 2008, patent pending.
Book Chapters:
  • Rowe, Laura; Teasley, Krystal; Qu, Xiaoge; Ensor, Mark; Deo, Sapna; Daunert, Sylvia. “Recombinant Aequorin Based Systems for Biomarker Analysis”, Handbook of Biosensors and Biochips, John Wiley & Sons, 2007.
  • Rowe, Laura; El Khoury, Graziella; Lowe, Christopher. “Affinity Chromatography: A Historical and Prospective Overview”, Biopharmaceutical Production Technology, 225-282 2012.
  • Dikici, Emre; Rowe, Laura; Moschou, Lisa; Rothert, Anna; Deo, Sapna; Daunert, Sylvia. “Luminescent Proteins: Applications in Microfluidics and Miniaturized Analytical Platforms”, Photoproteins in Bioanalysis, Wiley-VCH, 2006
Journal Articles:
  • Qu, Xiaoge; Rowe, Laura; Dikici, Emre; Ensor, Mark; Daunert, Sylvia. “Thermostable Aequorin Mutants”,  Bioanal. Chem 406 (23), 5639-5643, 2014.
  • El Khoury, Graziella; Rowe, Laura; Lowe, Christopher. “Biomimetic affinity ligand for immunoglobulins based on the multicomponent Ugi reaction”, Methods in Molecular Biology, 800, 57-74, 2012.
  • Rowe, Laura; Ensor, Mark; Mehl, Ryan; Daunert, Sylvia. “Modulating the bioluminescence emission of photoproteins by in vivo site-directed incorporation of non-natural amino acids”, ACS Chem. Biol 5 (5), 455-460, 2010, cover.
  • Rowe, Laura; Dikici, Emre; Daunert, Sylvia. “Expanding the Analytical Potential of Bioluminescent Proteins”, Chem. 81 (21), 8655-9201, 2009, cover.
  • Dikici, Emre; Qu, Xiaoge; Rowe, Laura; Millner, Lori; Logue, Courtney; Ensor, Mark; Deo, Sapna; Daunert, Sylvia. “Aequorin Variants with Improved Bioluminescence Properties”, PEDS, 22(4), 243-248, 2008.
  • Rowe, Laura; Combs, Kelly; Ensor, Mark; Deo, Sapna; Daunert, Sylvia. “Analytical applications of semi-synthetic photoprotein mutants: a time-resolved bioluminescent assay”, Chem., 80 (22), 8470-8476, 2008.
  • Rowe, Laura; Rothert, Anna; Logue, Courtney; Ensor, Mark; Deo, Sapna; Daunert, Sylvia. “Spectral tuning of photoproteins by partnering site-directed mutagenesis strategies with the incorporation of chromophore analogues”, PEDS, 21, 73-81, 2008.
  • Rowe, Laura; Deo, Sapna; Mirasoli, Mara; Shofner, Josh; Daunert, Sylvia. “Homogeneous immunoassay for cortisol in saliva using the bioluminescent protein aequorin”, Bioconjugate Chem., 18 (6), 1772-1777, 2007.
  • Doleman, Leslie; Davies, Logan; Rowe, Laura; Moschou, Lisa; Deo, Sapna; Daunert, Sylvia. “DNA hybridization assay for Plasmodium falciparum using the bioluminescent protein aequorin”, Chem., 79 (11), 4149-4153, 2007.
  • Rowe, Laura; Deo, Sapna; Ensor, Mark; Daunert, Sylvia. “Bioluminescent Properties of an Obelin Mutant in Varying pH and Solvent Solutions”, Proceedings of Bioluminescence and Chemiluminescence Symposium 2006, World Scientific Publishing, 131-134, 2007.
  • Rowe, Laura; Ensor, Mark; Daunert, Sylvia. “EF-hand Ca2+-binding bioluminescent proteins: effects of mutations and alternative divalent cations”, SPIE, 6449, 64490T/1-64490T/8, 2007.
  • Rowe, Laura; Ensor, Mark; Scott, Daniel; Deo, Sapna; Daunert, Sylvia. “Genetically engineered luminescent proteins in biosensing”, SPIE, 6098, 6098H/1-6098H/9, 2006

Memberships

  • American Chemical Society
  • Chemists Without Borders

Grants

  • Pittsburgh Conference Memorial National College Grant, Pittsburgh Conference, Instrument Grant, 2014 ($9,500)
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Laura Rowe