Beth Scaglione-Sewell
Beth Scaglione-Sewell, Ph.D.
Associate Professor of Biology
Neils Science Center, Room 302
219.464.5390
beth.scaglionesewell@valpo.edu
Education
Ph.D. – Kansas State University (1992)
B.A – Simpson College (1985)
Interests
The regulation of growth and differentiation of cells. Specifically, Professor Scaglione-Sewell has been interested in regulators of the mammalian cell cycle that are adversely affected in colon cancer cell culture models. Techniques utilized in the laboratory include Western Blotting, Northern Blotting, cell culture, enzyme assays, and some electron microscopy.
Contributions
- “Review of the Aging of Physiological Systems.” In: Gerontological Nursing: Competencies for Care. – Plahuta, Janice, Hamrick-King, Jennifer and Beth Scaglione-Sewell. Ed. Kristen L. Mauk. Boston: Jones and Bartlett Publishers; 2010. pp.128-231.
- A Vitamin D3 analog induces a G1-Phase arrest in CaCo-2 cells by inhibiting Cdk2 and Cdk6: Roles of Cyclin E, p21Waf1 and P27Kip1., Endocrinology 141:3931-3939., (2000)
- Decreased PKC-alpha expression increases cellular proliferation and enhances the transformed phenotype of CaCo-2 cells, Cancer Research 58:1074-1081., (1998)