Michael Berberoglu
Assistant Professor of Biology
Neils Science Center, Room 208
Education
Post-Doc – The Ohio State University; Research in Muscle Biology and Disease (OSU/NCH); 2016
Ph.D. in Neuroscience – University of California, San Francisco (UCSF); 2012
B.S. in Biology – University of Nevada, Reno; 2006
Research Interests
Neurobiology; Developmental Biology; Stem Cells & Regeneration; Adult Neurogenesis; Neuronal Function and Disease; Zebrafish
The zebrafish has recently emerged as a comparable and useful model for brain studies, as adult zebrafish show a remarkable capability to regenerate tissues of the central nervous system, are continuously generating new neurons throughout the brain as adults, and possess many brain regions that are neuroanatomically conserved with mammals. Research in the Berberoglu Lab aims to: 1) Understand the factors that regulate adult neural progenitor and/or stem cell proliferation and the production of neurons in the adult brain (adult neurogenesis), and 2) Identify genes that are required for proper brain development and neuronal function. We are currently investigating the role of Rbfox proteins in the development and function of neurons within the forebrain. Rbfox proteins have been implicated in a number of neurodevelopmental and neuropsychiatric disorders including Anxiety, Epilepsy, Schizophrenia, and Autism. Our work aims to understand whether Rbfox proteins are required for telencephalic neuronal development and function, and whether this has implications in behavior. We are also studying the role of Rbfox proteins in the development of the hindbrain, and aim to determine whether Rbfox proteins regulate neurogenesis within the cerebellum normally and during regeneration.
Contributions
- Ma, F., Dong, Z., and Berberoglu, M.A.* (2019). Expression of RNA-binding protein Rbfox1l demarcates a restricted population of dorsal telencephalic neurons within the adult zebrafish brain. Gene Expr. Patterns 31: 32-41. (*Corresponding author)
- Berberoglu, M.A., Gallagher, T.L., Morrow, Z.T., Talbot, J.C., Hromowyk, K.J., Tenente, I.M., Langenau, D.M., Amacher, S.L. (2017). Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish. Dev. Biol. 424: 162-180.
- Duy, P.Q., Berberoglu, M.A., Beattie, C.E., Hall, C.W. (2017). Cellular responses to recurrent pentylenetetrazole-induced seizures in the adult zebrafish brain. Neuroscience 349: 118-127.
- Berberoglu, M.A.,# Dong, Z.,# Li, G., Zheng, J., Martinez, L.C., Peng, J., Wagle, M., Reichholf, B., Petritsch, C., Li, H., Pleasure, S., Guo, S. (2014). Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells. J. Neurosci. 34: 13911-13923. (#Co-first author)
- Mueller T, Dong Z, Berberoglu MA, Guo S. (2011). The dorsal pallium in Zebrafish, Danio rerio (Cyprinidae, Teleostei). Brain Res. 1381: 95-105.
- Mathur P, Berberoglu MA, Guo S. (2011). Preference for ethanol in zebrafish following a single exposure. Behav. Brain Res. 217: 128-133.
- Berberoglu MA, Dong Z, Mueller T, Guo S. (2009). fezf2 expression delineates cells with proliferative potential and expressing markers of neural stem cells in the adult zebrafish brain. Gene Expr. Patterns 9: 411-422.
- Andrews GL, Tanglao S, Farmer WT, Morin S, Brotman S, Berberoglu MA, Price H, Fernandez GC, Mastick GS, Charron F, Kidd T. (2008). Netrin-dependent and independent roles for Dscams in embryonic axon guidance. Development 135: 3839-3848.
- Philips GT, Stair CN, Young Lee H, Wroblewski E, Berberoglu MA, Brown NL, Mastick GS. (2005). Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type. Developmental Biology 279: 308-321.