Patrice G. Bouyer

20140630 JLH Patrice Bouyer-002Associate Professor of Biology

Neils Science Center, 301


Ph.D. – René Descarte University, Paris (1998)
DEA (Masters) – René Descarte University, Paris (1994)
Maîtrise de Physiologie mention pharmacologie – University of Poitiers, France (1993)
Licence de Biologie Cellulaire mention Physiologie – University of Poitiers, France (1992)
Diplôme d’études universitaires générales (DEUG) – University of Poitiers, France (1990)

Research Interests

Professor Bouyer’s research focuses on the regulation of fluid transport in colonic and upper airway epithelial cells. Impairment of this biological function is the hallmark of diseases such as secretory diarrhea or cystic fibrosis. The laboratory is currently investigating the role of two protein kinases C in the control of fluid secretion by the Na-K-2Cl cotransporter.


Bouyer PG, Tang X, Weber CR, Shen L, Turner JR & Matthews JB. 2013. Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1.  Am J Physiol Gastrointest & Liver Physiol 304: G142-156.

Chlenski A, Guerrero LJ, Salwen HR, Yang Q, Tian Y, Morales La Madrid A, Mirzoeva S, Bouyer PG, Xu D, Walker M & Cohn SL. 2011. Secreted Protein Acidic and Rich in Cysteine Is a Matrix Scavenger Chaperone. PLoS One, 6: e23880.

Tang J, Bouyer P, Mykoniatis A, Buschmann M, Matlin, KS & Matthews JB. 2010. Activated PKCδ and PKCϵ inhibit epithelial chloride secretion response to cAMP via inducing internalization of the Na+-K+-2Cl– cotransporter NKCC1. J Biol Chem, 285: 34072-34085.

Mykoniatis A, Shen L, Fedor-Chaiken, M, Tang J, Tang X, Worrell RT, Delpire E, Turner JR, Matlin KS, Bouyer P*, & Matthews JB. 2010. Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway. Am J Physiol Cell Physiol, 298: C85-97 (* senior corresponding author).