Jeffrey Pruet

Assistant Professor of Chemistry

Center for the Sciences 206
219.464.6564
jeffrey.pruet@valpo.edu

Education

Ph.D. in Organic Chemistry – University of Texas (2012)
B.S. – Louisiana State University (2006)

Research Interests

My research is aimed at developing small-molecule therapeutics. Deazaguanines and Pterins are classes of heterocycles which have a broad range of applicability in the medicinal field. Exploring new reactions which allow for rapid diversification of these heterocycles would thus lead to large libraries of potentially therapeutic agents. One such application would be selective inhibition of fungal methionine synthase, paving the way for new anti-fungal drugs.

Contributions

  • P.A.Wiget; L.A. Manzano; J.M. Pruet; G. Gao; R. Saito; A.F. Monzingo; J.R. Jasheway; J.D. Robertus; E.V. Anslyn, “Sulfur incorporation generally improves Ricin inhibition in pterin- appended glycine-phenylalanine dipeptide mimics” Bioorg. Med. Chem Lett., 2013 23, 6799-6804
  • R Saito; J.M. Pruet; L. A. Manzano; K. Jasheway; A.F. Monzingo; P.A.Wiget; I. Kamat; E.V. Anslyn; J.D. Robertus, “Peptide-conjugated pterins as inhibitors of Ricin Toxin A” J. Med. Chem., 2013 56(1), 320-329
  • J.M. Pruet; R. Saito; L. Manzano; K. Jasheway; P. Wiget; I. Kamat; E. Anslyn; J. Robertus, “Optimized 5-membered heterocycle-linked pterins for the inhibition of Ricin Toxin A” ACS Med. Chem. Lets., 2012, 3, 588-591
  • J. M. Pruet; K. R. Jasheway, L. A. Manzano, Y. Bai, E. V. Anslyn, J. D. Robertus, “7-Substituted pterins provide a new direction for ricin A chain inhibitors” Eur. Journal of Med. Chem., 2011, 46(9), 3608-3615

Memberships

    • American Chemical Society
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Jeff Pruet